Seeing a high A/G ratio on your blood test results can be a bit confusing. A/G ratio, or Albumin/Globulin ratio, compares the amount of albumin (a protein that keeps fluid in your blood vessels) to the amount of globulins (proteins involved in immunity and other functions). Typically, this ratio should be slightly above 1.0.
A high A/G ratio generally indicates a lower-than-normal level of globulins. While it's not always cause for immediate alarm, it's important to understand potential causes. One possibility is genetic immune deficiencies, in which the body doesn't produce enough infection-fighting antibodies (globulins). Certain types of leukemia can also affect globulin production.
Importantly, a high A/G ratio can also be caused by errors in testing and is sometimes simply a variation within a normal range.
If your blood test shows a high A/G ratio, the next step is to discuss it with your doctor. They will consider your medical history, other lab results, and perform a physical exam to determine the underlying cause and recommend appropriate follow-up tests or treatment. Don't panic, but do be proactive in understanding what your results mean for your health.
